AAA237, AN SKP2 INHIBITOR, SUPPRESSES GLIOBLASTOMA BY INDUCING BNIP3-DEPENDENT AUTOPHAGY THROUGH THE MTOR PATHWAY

AAA237, an SKP2 inhibitor, suppresses glioblastoma by inducing BNIP3-dependent autophagy through the mTOR pathway

Abstract Background Glioblastoma (GBM) is the most common brain tumor with the worst prognosis.Temozolomide is the only first-line drug for GBM.Unfortunately, the resistance issue is a classic problem.Therefore, it is q60 headers essential to develop new drugs to treat GBM.As an oncogene, Skp2 is involved in the pathogenesis of various cancers incl

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